Cyclosporine and general medicine, is a kind of special drugs. When used to maintain stable blood concentration to reduce organ rejection after transplantation and toxic and side effect of. Many drugs have on cyclosporine absorption, metabolism, excretion secretion, impact, thereby reducing or increasing the drug concentration in blood. So a correct understanding of cyclosporine is renal required course.

1are known to have toxic effects on renal drug combination, should be closely monitored in kidney function, renal function was significantly impaired when, in order to reduce the drug dosage, or alternate dosing. These drugs include: acyclovir, aminoglycoside antibiotics ( including gentamycin and tobramycin ), amphotericin, ciprofloxacin, melphalan, methoxy Bian ( + ammonia pyrimidine sulfonamide SMZ ), vancomycin.

2nonsteroidal anti-inflammatory drug itself can lead to renal damage, therefore, with cyclosporine combined with or increase the non-steroidal anti-inflammatory drug dose in the initial stage, we should pay special attention to.

3when cyclosporine with furosemide and mannitol combined with even the careful, because they can increase cyclosporine renal toxicity.

4cyclosporine increased use of lipid-lowering statins ( fluvastatin except) and colchicine on muscle potential toxicity ( including muscle pain and muscle weakness ), myositis and rhabdomyolysis risk. Therefore in the decision and cyclosporine a combined with medication to listen to advice. Lescol ( fluvastatin ) can only be in transplant patients safety in the use of lipid-lowering statins.

5 increases cyclosporine blood concentration of the drug are: chloroquine, fluconazole, ketoconazole, itraconazole, certain macrolide antibiotics ( including erythromycin and josamycin, pristinamycin ), doxycycline, and some calcium antagonists such as diltiazem ( diltiazem ), nicardipine and verapamil, Vera Pammy, methoxy metoclopramide, oral contraceptives, danazol, amiodarone, propafenone, cholic acid and its derivatives.

6 reduction of cyclosporine blood concentration of the drug are: barbiturates, carbamazepine, phenytoin, rifampin, analgin, octreotide, sulfamethazine intravenous injection and sulfamethoxazole in intravenous injection.

7cyclosporine reduces prednisolone clearance rate, but a large dose of methylprednisolone increases blood cyclosporine levels.

8a few cases showed allopurinol ( anti gout drugs ) may also increase blood cyclosporine concentrations.

9 in the use of cyclosporine during treatment, the effect of vaccination can reduce as far as possible, using live attenuated vaccine.

10cyclosporine reduces digoxin plasma clearance rate, can lead to digoxin poisoning.

11taking cyclosporine, occurrence of gingival hyperplasia renal can cause the same symptoms do not take nifedipine.

12taking cyclosporine, drink grapefruit juice can increase the cyclosporine bioavailability.